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- Take the extended-release form of metronidazole (flagyl er) on an empty stomach, at least 1 hour before or 2 hours after eating a meal.
- Long-term, oral-dosing studies in the rat showed statistically significant increases in the incidence of various neoplasms, particularly in mammary and hepatic tumors, among female rats administered metronidazole over those noted in the concurrent female control groups.
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- The current outpatient treatment recommendation is ceftriaxone 250 mg as a single intramuscular dose, followed by doxycycline 100 mg orally twice daily and metronidazole 400 mg twice daily, for 14 days.
- Do not, however, take metronidazole without first talking to your doctor if you are pregnant.